منابع مشابه
Replication timing of genes and middle repetitive sequences.
DNA replication in mammals is temporally bimodal. "Housekeeping" genes, which are active in all cells, replicate during the first half of the S phase of cell growth. Tissue-specific genes replicate early in those cells in which they are potentially expressed, and they usually replicate late in tissues in which they are not expressed. Replication during the first half of the S phase is, therefor...
متن کاملJunk DNA - repetitive sequences
Eukaryote and also human DNA contains large portion of noncoding sequences. As for the coding DNA, the noncoding DNA may be unique or in more identical or similar copies. DNA sequences with high copy numbers are then called repetitive sequences. If the copies of a sequence motif lie adjacent to each other in a block, or an array, we are speaking about tandem repeats, the repetitive sequences di...
متن کاملAligning sequences with repetitive motifs
Pairwise sequence alignment is among the most intensively studied problems in computational biology. We present a method for alignment of two sequences containing repetitive motifs. This is motivated by biological studies of proteins with zinc finger domain, an important group of regulatory proteins. Due to their evolutionary history, sequences of these proteins contain a variable number of dif...
متن کاملTranscriptional "silencer" element in rat repetitive sequences
The enhancer elements from either simian virus 40 or murine sarcoma virus activate the expression of a transfected rat insulin 1 (r11) gene when placed within 2.0 kilobases or less of the rl1 gene cap site. Inclusion of 4.0 kilobases of upstream r11 sequence, however, results in a substantial reduction in the enhancer-dependent insulin gene expression. These observations suggested that a negati...
متن کاملHighly repetitive DNA sequences in cyanobacterial genomes.
We characterized three distinct families of repeated sequences in the genome of the cyanobacterium Calothrix sp. strain PCC 7601. These repeated sequences were present at a level of about 100 copies per Calothrix genome and consisted of tandemly amplified heptanucleotides. These elements were named short tandemly repeated repetitive (STRR) sequences. We used the three different Calothrix STRR s...
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ژورنال
عنوان ژورنال: Nature
سال: 1984
ISSN: 0028-0836,1476-4687
DOI: 10.1038/311217b0